The role of the vascular KATP channel in septic models

نویسنده

  • Yi-Ling Chan
چکیده

Chan, Y.-L., Orie, N. N., Singer, M., and Clapp, L. H. (2007). Inflammatory mediators enhance expression of vascular ATP-sensitive potassium channels. Intensive Care Med. 33:S120. Chan, Y.-L., Orie, N. N., Singer, M., and Clapp, L. H. (2008). Enhanced expression of vascular KATP channels in an in vitro model of sepsis. Fundam. Clin. Pharmacol. 22:S34. Chan, Y.-L., Stidwill, R., Taylor, V., Clapp L. H., and Singer, M. (2008). Midazolam unmasks blood pressure responses to the KATP pore blocker in septic rats. Intensive Care Med. 34:S121. Chan, Y.-L., Taylor V., Stidwill, R., Clapp L. H., and Singer, M. (2009). Sympathetic tone and vascular KATP channel activity. Intensive Care Med. 35:S31.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis and Vasorelaxant Effect of 9-aryl-1,8-acridinediones as Potassium Channel Openers in Isolated Rat Aorta

ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...

متن کامل

Synthesis and Vasorelaxant Effect of 9-aryl-1,8-acridinediones as Potassium Channel Openers in Isolated Rat Aorta

ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...

متن کامل

Role of KATP channels in sepsis.

Sepsis is an infection-induced inflammatory syndrome responsible for approximately 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure. One potential target is the ATP-sensitive potassium (K(ATP)...

متن کامل

Role of L-arginine/NO/cGMP/KATP channel signaling pathway in the central and peripheral antinociceptive effect of thymoquinone in rats

Objective(s): Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modulatory role in pain perception. Previous studies have shown that thymoquinone exerts antinociceptive effects; however, the mechanisms underlying antinociception induced by thymoquinone have not been fully clarified. The aim of the present study was to evaluate the role of L-arginine/NO/cGMP/KATP c...

متن کامل

Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats

Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels w...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011